Acidosis láctica, en relación con insuficiencia renal aguda y metformina, tratada con hemodiálisis con bicarbonatoA Case of lactic acidosis related to acute renal . Lactic acidosis is a medical condition characterized by the buildup of lactate ( especially L-lactate) in the body, which results in an excessively low pH in the. Review Article from The New England Journal of Medicine — Lactic Acidosis.
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Because of the high solute concentration of the rumen fluid under such conditions, considerable water is translocated from the blood to the rumen along the osmotic potential gradient, resulting in dehydration which cannot be relieved by drinking, and which can ultimately lead to hypovolemic shock.
Regulatory, Integrative and Comparative Physiology. Rev Med Chile ; Drug Saf ; Report of one case. Nutritional ecology of the ruminant. Lactic acidosis is a serious complication of metformin therapy and is more frequent in patients with kidney failure and other intercurrent complaints. He was admitted with abdominal pain, nausea, vomiting, diarrhea and loss of consciousness.
This section needs additional citations for verification. This page was last edited on 16 Novemberat D ICD – In some situations, hemofiltration purification of the blood is temporarily required. Can acute overdose of metformin lead to lactic acidosis?
Influence of the composition of the ration and the feeding frequency on ph-regulation in the rumen and on feed in-take in ruminants. Reptileswhich rely primarily on anaerobic energy metabolism glycolysis for intense movements, can be particularly susceptible to lactic acidosis. Therefore, hydrogen cation concentration rises and causes acidosis.
Bicarbonate haemodialysis as a treatment of metformin overdose.
Hiperpotasemia extrema no fatal en un caso de acidosis láctica por sobreingesta de metformina
In domesticated ruminants, lactic acidosis may occur as a consequence of ingesting large amounts of grain, especially when the rumen population is poorly adapted to deal with grain. June Pages The excess hydrogen cations produced during lactic acidosis are widely believed to actually derive from production of lactic acid. In particular, during the capture of large crocodiles, the animals’ use of their glycolytic acidosks often alter the blood’s pH to a point where they are unable to respond to stimuli or move.
Lactic acidosis is lacticw serious complication of metformin therapy and is more frequent in patients with kidney failure and other intercurrent complaints. In this situation, glycolysis is increased to provide additional ATP, and the excess pyruvate produced is converted into lactate and released from the cell into the bloodstream, where it accumulates over time.
The net result is ATPthe energy carrier used by the cell for metabolic activities and to perform work, such as muscle contraction. Diabetes Obes Metab, 2pp.
Goldman-Cecil Medicine 25 ed. Views Read Edit View history. Full acldosis is only aviable in PDF. If oxygen supply is inadequate hypoxiathe mitochondria are unable to continue creating ATP at a rate sufficient to meet the cell’s energy needs.
Montoliu J, Revert L. Subscribe to our Newsletter. Lactate production is buffered intracellularly, e. Most cells in the body normally metabolize glucose to form water and carbon dioxide in a two-step process.
Lactic acidosis is also a consequence of the kactica causing rigor mortis. Am J Hypertens ; Unsourced material may be challenged and removed. JAMA,pp. Changes in plasma potassium concentration during acute acid-base disturbances.
La acidosis asociada al uso de metformina, es de baja incidencia pero elevada mortalidad Risk of fatal acidosiis nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Print Send to a friend Export reference Mendeley Statistics. Pharmacol Res, 30pp. Risk of fatal and non fatal lactic acidosis with metformin use in type 2 diabetes mellitus. Recibido el 1 de septiembre deaceptado el 23 de diciembre de