Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.
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The presence of lesional skin T-cell clonality in FM does not portend a poorer prognosis.
He gave a history of childhood atopic dermatitis with mild asthma but was off all medications since several years. Koilonychia Nail clubbing behavior: Contributed by Mowafak Hamodat, M.
Considering the rapid and complete response to antileprosy treatment in 7 cases of Alopecia mucinosa three cases described in this paper and the four similar mucinpsa described earlier[ 10 ]it is most unlikely that the response was a natural remission of the disease. This is in contrast to cases of Alopecia mucinosa reported in alopeciw including the first report of six cases by Pinkus[ 3 ] in which multiple erythematous papules and plaques micinosa over the head alopecis neck region.
Topical corticosteroids mid to high potency —response expected within 3 months Tretinoin 0. FM may affect children it is very rare in infants and toddlersbut is most common in the 4th to 6th decades.
Response within 3 months; recurrence may occur upon discontinuation. Clinical, histological and immunological remission with minocycline. For solitary or localized lesions, topical agents are first line because they are low risk, easy to administer, and low cost. In general, patients with idiopathic FM tend to be younger and have fewer and more localized lesions on the head or neck.
Hinduja Hospital, Mahim, Mumbai, India. Fitzpatrick’s Dermatology in General Medicine.
Alopecia mucinosa — codes and concepts open. On hair-bearing skin e. Mycosis mucjnosa associated follicular mucinosis on posterior scalp. The presence of intrafollicular mucin can be confirmed with colloidal iron tissue stains.
DermNet NZ does not provide an online consultation alooecia. A clinical diagnosis of leprosy was considered and she was asked to apply a moisturizing cream and kept under observation as a biopsy was refused. A reaction pattern in follicular epithelium. The objective alopecis this paper is to draw attention to an unusual finding, that is, rapid and complete response of Alopecia mucinosa to antileprosy treatment with no subsequent relapse over fairly long periods of posttreatment observation.
Follicular Mucinosis (Alopecia Mucinosa)
If recurrence is noted upon withdrawal, consider reinstitution of either the same or a new therapy. All our cases presented with single lesions which demonstrated hypoesthesia.
Benign or idiopathic type of Alopecia mucinosa occurs in children and young adults and has a variable natural course and does not have any specific effective therapy. At this stage it is pertinent to reflect on the vagaries and irony of the practice of medicine.
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It is characterised by bald patches of skin in which hair follicles are prominent. Avoid use in patients under age 8.
Photodynamic therapy is an option, but availability is more limited and may be more jucinosa. Therefore the final clinic-pathologic diagnosis was Alopecia mucinosa. Follicular mucinosis presenting as an acneiform eruption: This is an open-access article distributed under the terms of the Mucionsa Commons Attribution-Noncommercial-Share Alike 3.
It may be due to dysfunctional T muxinosa inducing mucin production by fibroblasts surrounding follicular epithelium, or due to excess production of mucin by follicular keratinocytes. Histological features of the underlying disease are present in secondary alopecia mucinosa. You must be a registered member of Dermatology Advisor to post a comment. Indomethacin 25mg orally, twice daily; monitor for gastrointestinal adverse effects, electrolytes, and creatinine.
Although a definite histological diagnosis of leprosy could not be rendered, based on the clinical suspicion the patient was started on MDT, with Rifampicin mg once a month and dapsone mg daily according to the standard World Health Organization WHO protocol.
Alopecia Mucinosa Responding to Antileprosy Treatment: Are we Missing Something?
The etiology is not known. Follicular mucinosis as the only pathology may be seen in facial lesions of clinically suspected leprosy in children and young adults.
He had been advised topical Tretinoin and Deoximetasone creams, which he used without any improvement over 3 months. These lesions had persisted for months, had even grown in size in case 2, and not responded to topical steroids and tretinoin in case 3. A month later the patch had enlarged minimally, the surface was dry and showed follicular prominences, however, no erythema was seen [ Figure 1a ].
The T-lymphocyte, the mucinosis epithelial interstitium and immunostimulation. Secondary alopecia mucinosa should be treated appropriately for the underlying skin disease, particularly if it is cutaneous T-cell lymphoma.
Pathophysiology Controversy exists as to whether the disease is a neoplastic process or a reactive process.