ARIXTRA PRESCRIBING INFORMATION PDF

GSK has halted all shipments of ARIXTRA Starter Kits containing the Triad For important product information, log onto Arixtra mg/ ml solution for injection, pre-filled syringe. 2. .. Detailed information on this medicinal product is available on the website of the European . Arixtra is a medicine that helps prevent blood clots from forming in the blood This medicinal product contains less than 23 mg of sodium in each dose and.

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Hull R, Pineo G. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery. Postoperative wound infection, postoperative hemorrhage, fever, surgical infformation reaction, presribing, hypertension, pneumonia, vomiting.

Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: Discontinue oral anticoagulants prior to initiation of fondaparinux 1 40 If coadministration is essential, monitor patients closely 1 In healthy adults, distributes mainly in blood and only to a minor extent in extravascular fluid. Comparison of fondaparinux and enoxaparin in acute coronary syndromes.

Anticoagulant effects may persist for 2—4 days following discontinuance of therapy in patients with normal renal function i. Administer by sub-Q injection into fatty tissue, alternating injection sites daily e.

Patients undergoing hip-fracture, hip- or knee-replacement surgery: Research Triangle Park, NC: A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement. LMWHs or fondaparinux generally preferred over heparin for initial treatment of acute venous thromboembolism; however, heparin may be preferred in patients with renal impairment.

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Am J Health-Syst Pharm. If PCI is performed while a patient is receiving fondaparinux, administer an additional anticoagulant with anti-factor IIa antithrombin activity because of the risk of catheter thrombosis. If fondaparinux therapy is to be continued after hospital discharge, importance of instructing patient on proper administration of the drug, including injection technique. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

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FDA alerts for all medications. A new synthetic pentasaccharide for thrombosis prevention. To view content sources and attributions, please refer to our editorial policy. ACCP recommends fondaparinux as an option for thromboprophylaxis in acutely ill, hospitalized medical patients at increased risk of thrombosis.

If coadministration is essential, monitor patients closely 1 Subscribe to receive email notifications whenever new articles are published. Anticoagulation results from rapid inhibition of factor Xa by antithrombin III bound to fondaparinux about fold greater than innate activity.

No specific dosage recommendations; prfscribing, careful attention to dosage directions recommended. Patients undergoing abdominal surgery: The activity of fondaparinux sodium is measured based prescribong plasma drug concentrations quantified by anti-factor Xa activity using fondaparinux as the calibrator.

Arixtra Monograph for Professionals –

Importance of patients informing clinicians including dentists that they are receiving fondaparinux therapy before scheduling any invasive procedures. Importance of advising patients who have had neuraxial anesthesia or spinal puncture to monitor for manifestations of spinal or epidural hematoma e.

Natural rubber-containing medical devices; user labeling. Clin Appl Thromb Hemost. Risk also increased by history of traumatic or repeated epidural or spinal puncture, spinal deformity, or spinal surgery.

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In general, pharmacologic thromboprophylaxis is recommended only in such patients considered to be at high risk of venous thromboembolism. Dosages for fondaparinux sodium and heparin, heparinoids, or LMWHs cannot be used interchangeably on a unit-for-unit or mg-for-mg basis 1 as they differ in the manufacturing process, anti-factor Xa and antithrombin activity, and dosage.

Epidural or spinal hematoma reported with concurrent use of anticoagulants e. Avoid concomitant use of drugs that increase risk of bleeding informatlon essential for management of underlying condition e. Print this page Add to My Med List.

If pharmacologic prophylaxis is indicated in patients undergoing general surgery, ACCP states that an LMWH or low-dose heparin is preferred; fondaparinux may be considered when both an LMWH and heparin are contraindicated or not available. Treatment and prevention of heparin-induced thrombocytopenia: Prevention of postoperative DVT and PE in patients undergoing presctibing, hip-replacement, or knee-replacement surgery.

Following a single 7. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip- fracture surgery.

Discontinue oral anticoagulants prior to initiation of fondaparinux 1 Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: J Am Coll Cardiol. Synthetic pentasaccharides do not cause platelet activation by antiheparin-platelet factor 4 antibodies. Bounameaux, H, Perneger Ptescribing.

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