Veja grátis o arquivo ATLAS DE HEMATOLOGIA (McDONALD) enviado para a disciplina de Hematologia Categoria: Aulas – 18 – Atlas de hematologia, – ,-~,. 1r6logo (Ie b pl”imcra t,-dicioll_ _ Prcfacio de b quinta ec:lici6n._ _ Prcf{lcio de ]a pl;mcra edicibn t. “. Title, Atlas de hematología. Authors, George A. McDonald, J. Paul, Bruce Cruickshank. Edition, 5, illustrated, reprint. Publisher, Médica Panamericana,

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Cytogenetics helps to detect abnormalities,especially in chromosomes 11 and In fe blood film, lymphocyte lysates, resulting from viral infection, present similar aspects to those described by Gumprecht atlaa refer to lymphocyte lysates at CLL Manual de hematologia de Williams. Annals of Oncologyv. Additional tests may be ordered, such as bone marrow biopsy for exclusion of idiopathic cytopenias; detection of genetic abnormalities, principally of a deletion of chromosomes 17 [del 17p ] and 11 [del 11q ]; flow cytometry to evaluate ZAP and CD38 expression, whose presence mddonald poor prognosis; and computed tomography CT for the staging of the disease Please refer to our privacy policy for more information on privacy at Loot.

World Health Organization classification of tumours of haematopoietic and lymphoid tissues.

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In face of the ambiguous use of the term Gumprecht shadows in clinical situations of distinct prognosis and evolution, it would be quite pertinent to keep using it in cases of CLL, principally knowing that absolute lymphocytosis in peripheral blood is not always a sign of malignancy.

On the other hand, in lymphomas, although cells express B-lymphocyte and CD5 surface antigens, they normally do not express CD The expression Gumprecht shadows historically refers to lymphocyte lysates commonly observed in patients with chronic lymphocytic leukemia CLL. Email address subscribed successfully.

International Agency for Research on Cancer, The microscopic examination of blood cells is surely an essential step for the diagnosis of CLL: However, only the morphological aspects of lymphocytes do not allow differentiation between B- and T-CLL type.

Gumprecht; chronic lymphocytic leukemia; viruses. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: In this case, lymphocytosis occurs when old cells accumulate, because the apoptosis mechanism is impaired All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.


Blood Cellsv. Ann Biol Clinv. Although more sophisticated methods, such as flow cytometry and cytogenetics, are currently used to refine this diagnosis 29the initial suspicion comes from cell morphology observed in the blood film.

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To access your account information you need to be authenticated, which means that you need to enter your password to confirm that you are indeed the person that the cookie claims you to be. It should be noted that the mechanisms of lymphocyte destruction in CLL and in viral diseases are distinct. Basket cells or shadow cells of Gumprecht: We never store sensitive information about our customers in cookies. The inappropriate use of this term may cause great anxiety in individuals who receive this observation in their blood count, as well as to their families, since information on the internet is available to any person and is frequently used to clear doubts on medical terms.

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The expression Gumprecht shadows derived from the German researcher Ferdinand Adolph Gumprecht 42as he observed the blood films of patients with chronic lymphocytic leukemia CLL Mcdona,d. Persistent cookies are stored on your hard disk and have a pre-defined expiry date.

Atlas de Hematologia

Escola paulista de medicina. The serum levels of immunoglobulins CD20 and CD79b are significantly reduced in comparison to normal B-lineage cells. Please click the link in that email to activate your subscription.

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Since the presence of viroses may cause the appearance of images similar to those observed in CLL because of lymphocyte lysis, a literature review was undertaken by searching the word Gumprecht referring to images of lymphocyte lysates that occur in viral diseases. More sophisticated techniques are required for the proper classification In a web search engine commonly used to qtlas doubts on medical terms, there are countless pages where Gumprecht shadows are associated with CLL.


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Atlas de hematología – George A. McDonald, J. Paul, Bruce Cruickshank – Google Books

Thus, the most frequently used textbooks in English or Portuguese5,15,in our setting do not refer to this term, although older literature values Gumprecht shadows for the diagnosis of CLL. A literature review revealed that hematolpgia term is restricted to CLL cases, and should not be applied to lymphocytosis-related conditions.

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CLL is suspected when the blood film reveals an expressive increase in uniform-appearing lymphocytes and the presence of destroyed lymphocytes.

Besides, serum determination of lactate dehydrogenase LDHbilirubin, immunoglobulins, and antiglobulins composes the test panel currently used to diagnose CLL 6. A search in the PubMed database using terms Gumprecht chronic lymphocytic leukemia revealed just five reports 4, 12, 13, 36, 37what confirms that the term has fallen into disuse.

It is benign in comparison to other leukemias, shows slow evolution and marked leukocytosis in the blood The World Health Organization WHO describes CLL as a neoplasm of small B lymphocytes, with slightly irregular membrane present in peripheral blood, bone marrow, spleen and lymph nodes, along with prolymphocytes and paraimmunoblasts that proliferate in the infiltrated tissues CLL is a relatively rare lymphoproliferative disorder. The expression Gumprecht shadows must be used only for cases of CLL, not to describe ruptured lymphocytes present in other situations with lymphocytosis, associated with either viral diseases or other causes.

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