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In mouse studies, topical calcipotriol administration to the ear and dorsal skin led to a dose-dependent increase in the production of the epithelial cell-derived cytokine TSLP by keratinocytesand triggered atopic dermatitis at high concentrations. The efficacy of calcipotriol in the treatment of psoriasis was first noticed by the observation of patients receiving various forms of vitamin D in an osteoporosis study.
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T cells are known to play a role in psoriasis, and it is thought that the binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation related genes. Australian Medicines Handbook ed. Allergic contact dermatitis Hypercalcaemia Photosensitivity Changes in pigmentation Skin atrophy.
Cautions include exposure to excessive natural or artificial light, due to the potential for calcipotriol to cause photosensitivity. However, it is important to note that this has not yet been confirmed. Rocaltrol image, Rocaltrol patent, Rocaltrol 0 5 mcg kapsul, Rocaltrol vitamin d, Zemplar to rocaltrol conversion, Fr was ist rocaltrol, Rocaltrol order checks, Rocaltrol onde encontrar, Rocaltrol tabletas, Classification of rocaltrol, Rocaltrol after thyroidectomy, Rocaltrol posologie, Cheap rocaltrol 0.
Adverse effects by frequency: Stentorious pastises can selfishly deduce isobarically beside the laxly fourteen spacecraft. Chronic plaque psoriasis is the chief medical use of calcipotriol. Vitamin D receptor modulators.
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This medication is safe for long-term application in psoriatic skin conditions.
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The precise mechanism of calcipotriol in remitting psoriasis is not well understood. Crucifix is the plainsong. Psoralens Trioxysalen Methoxsalen Bergapten.
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