CATHFLO PACKAGE INSERT PDF

PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .

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There are no adequate and well-controlled studies in pregnant women. Hopefully if it is de-clotted properly at that treatment, it will function properly for the next treatment. Severe Antifibrinolytic agents, including tranexamic acid, can antagonize the actions of thrombolytic agents. The authors concluded that fish oil supplementation in doses of 36 grams per day does not have a statistically significant effect on the INR of patients receiving chronic warfarin therapy. Moderate An additive risk of bleeding may be packate in patients receiving thrombolytic agents and anticoagulants.

Bloomington St, Greencastle,IN Although clinical practice guidelines recommend expanded use of alteplase at 3 to 4. Although these effects have not been confirmed in published medical literature or during clinical studies, clinicians should consider using methylsulfonylmethane, MSM with caution in patients who are taking thrombolytic agents until data confirming the safety of this drug combination are available.

Hang the reconstituted vial of alteplase from the plastic molded capping attached to the bottom of the vial. Major Two separate studies have shown that concomitant administration of IV nitroglycerin can compromise the therapeutic efficacy of alteplase. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.

Cathflo Activase (alteplase) dose, indications, adverse effects, interactions from

It is possible that the use of green tea may increase the risk of bleeding if coadministered with thrombolytic agents. Alteplase is contraindicated in patients with severe uncontrolled hypertension. Major An additive risk of bleeding may be seen in patients receiving thrombolytic agents with thrombin inhibitors. In many cases, patients received concomitant ACE inhibitors. In clinical trials, alteplase was administered by catheter-directed intra-arterial administration. Remove from the vial the amount of drug that is not needed for the indication-specific dose for the patient.

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Data from published studies and case reports on alteplase use in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes. This includes patients receiving thrombolytic agents, however, no clinical data are available. Certain causes of catheter dysfunction should be considered before treatment with Cathflo Activase e. Invert the two vials so that the vial of alteplase is on the bottom and allow the entire amount of water to flow into the alteplase vials about 0.

Hypersensitivity Hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of Cathflo Activase. This implies that a dose-related effect of fish oil on warfarin may be possible. My attempts to identify any research or even anecdotal data have not been successful and I’d be really interested in your thoughts. Following instillation of second dose, check catheter function 30 minutes and, if needed, minutes following second instillation.

Dosage & Administration – Cathflo® Activase® (alteplase)

Gently irrigate the catheter with 0. If signs of a hypersensitivity occur, discontinue alteplase and promptly institute appropriate therapy e.

Caution should be exercised with patients who have any condition for which bleeding constitutes a significant hazard. Children and Adolescents weighing 30 kg or more. The treatment of patients with minor neurological deficit or with rapidly improving symptoms is not recommended as the safety and efficacy in these patients has not been evaluated. Your email has been sent! Remove the appropriate indication-specific volume from the reconstituted vial using a syringe and needle.

If catheter function is restored, aspirate 4 to 5 mL of blood in patients weighing 10 kg or greater or 3 mL in patients weighing less than 10 kg to remove alteplase and residual clot. I found one instance where they infused 2mg over a 24 period? Bismuth Subsalicylate; Metronidazole; Tetracycline: Minor Agents that decrease clotting, such as thrombolytic agents, could decrease the efficacy of photosensitizing agents used in photodynamic therapy. Avoid vigorous suction during attempts to determine catheter occlusion to prevent damage to the vascular wall or collapse of soft-walled catheters.

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Cathflo Activase should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Powered by Higher Logic. Moderate Platelet aggregation may be impaired by venlafaxine due to platelet serotonin depletion, possibly increasing the risk of a bleeding complication e. Moderate Agents that may effect hemostasis including sulfinpyrazone, can increase the likelihood of hemorrhage if administered during or immediately before therapy with thrombolytic agents.

Patients should be closely monitored for signs and symptoms of bleeding when a thrombolytic agent is administered with vilazodone.

Slight foaming upon reconstitution may occur; standing undisturbed for several minutes is sufficient to allow dissipation of any large bubbles. If the psckage vial is used, the needle should be inserted away from the puncture mark cathfpo by the transfer device. In one study of patients with acute iliofemoral DVT, 0.

Systemic alteplase can cahflo significant, sometimes fatal, internal or external bleeding, especially at arterial and venous puncture sites. Due to an increased risk for bleeding, alteplase is contraindicated in patients being treated for acute myocardial infarction or pulmonary embolism with the following concomitant conditions: Pre-treatment with oral anticoagulants is reported to be an independent risk factor for intracranial hemorrhage in thrombolytic-treated patients.

View videos and instructions for the recommended dosing and administration of Cathflo.

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Monitor patients treated with Cathflo Activase for signs of hypersensitivity and treat appropriately if necessary. Would you like to mark this message as the new best answer?

Alteplase may increase the risk of thromboembolic events in these conditions where there is a high likelihood of left heart thrombus, such as patients with mitral stenosis or atrial fibrillation. The risks of alteplase therapy may be increased in patients with major early infarct signs on CT e.

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