Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.

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Difrucaps developments are therefore needed to overcome these issues, so that 3DP systems can be successfully combined with conventional pharmaceutics. Eurand Minitabs can also be used as a sprinkle on food.

In this technology, a bilayer tablet was manufactured. This type of glyco-sensitive gel may have potential utilitiy in self-regulated drug releasing systems as well techno,ogy in dirfucaps applications, such as actuators, regulators and separation systems with glyco-sensitivity. Antigenantibody complex formation is of great importance as the cross-linking units in the gel due to such specific interaction.

Another new approach was enteric-coated, timed-release, press-coated tablets ETP tablets. The vessel is made of water-impermeable ethylene-co-vinyl acetate copolymer EVA and the cap is made of proprietary water-permeable blends of polycaprolactone TONE and flux enhancers 12.

These pellet-filled capsules provide for extended release of the drug in the gastrointestinal tract. Hydration of the technooogy engine leads to its expansion, which exerts a driving force against the ridge of the drug vessel.

Then, the beads are filled into hard gelatine capsules for ease of administration 18,19,20, Great interest is taken in site and time specific oral drug delivery to improve therapeutic efficacy. The etiology of the dreaded diseases can be linked to the release of the specific drugs through these systems, riffucaps would definitely result in the betterment of the therapy.

Diffucaps Customized Release Technology from Adare Pharmaceuticals

Using this novel technology, SkyePharma has developed Lodotra TMcontaining a rheumathoid arthritis drug. Although sustained and controlled drug delivery systems have acquired a lot of success and application in field of Pharmacy. When the capsule comes in contact with dissolution fluid, the plug gets swells, and after a lag time, the plug pushes itself outside the capsule and rapidly releases the drug.


The manufacturing process diffucapw of three steps: Positive thermosensitive pulsatile drug release using negative thermosensitive hydrogels. The central pathophysiology of epilepsy and the behavioral classification of convulsive events.

Int J Pharm Tech Res.

Diffucaps® Customized Release Technology | Adare Pharmaceuticals | CPhI Online

Pulsatile release time site or specific most often is achieved by using different polymers in coating layers or by changing the coating thickness. This system controls release rates for multiple ingredients within a single tablet in a programmed manner.

The Time Multiple Action Delivery System provides control release rate of multiple ingredients within a single tablet Due to their high efficiency and lack of undesirable adverse effects to the whole body, the stimuli-responsive feature of these systems is useful for treatment of patients. The Geomatrix TM technology is applied to achieve customized levels of controlled release of specific drugs and can achieve simultaneous release of two different drugs and different rates from a single tablet.

J Am Chem Soc. The individual particles had the same composition as the internal core, but the thickness of the external coating layer varied. Circadian variations seen in DOPA level in afternoon in case of Attention deficit syndrome7, 9, 10, Chemical stimuli induced pulsatile release: In thermo-responsive hydro gel systems, hydro diffkcaps undergo reversible volume changes in response to changes in temperature.

The drug loaded beads are coated with controlled release polymers water soluble and insoluble, pH dependent or independent to form a release rate controlling membrane.

In this, the beads with high density drug are compressed to form controlled release tablets. When this capsule comes in contact with the dissolution fluid, it swells, and after a lag time, the plug pushs itself outside the capsule and rapidly releases the drug. This technology is particularly suitable for drugs difducaps conventionally need multiple daily doses or drugs require customized release formulations.


In certain cases, immediate release of drug is undesirable. Author information Copyright and License information Disclaimer. This delay is introduced by the level of non-enteric release-controlling polymer applied ciffucaps drug-loaded beads. Assessing the abuse potential of an oral osmotic-controlled extended release OROS hydromorphone compared to immediate release hydromorphone. The lag time and onset of action are controlled by thickness and the viscosity grade of the polymer used.

Recent technologies in pulsatile drug delivery systems

Rapid advancement and newer developments in the field of drug delivery have diffuaps to the formulation of the pulsatile drug delivery system, which, on one hand, can be formulated with ease and, on the other hand, provides a significant amount of therapeutic benefits.

Orbexa technology is a multiparticulate system that enables high drug loading and is suitable for products that require granulation. The characteristic feature of the formulation was a well defined lag time followed by a drug trchnology with the enclosed active quantity being released at once. In this system, drug dfifucaps released when polymer undergoes swelling or deswelling phase in response to chemical reaction with membrane, alteration of pH and Inflammation induce3, 4, The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

Conte U, Maggi L. Gastric acid secretion is highest at night while gastric and small bowel motility and gastric emptying are all slower at night.

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