Épissage constitutif et alternatif. A) Schéma d’un événement d’épissage. L’intron excisé mène à la production d’un ARNm mature qui est exporté au cytoplasme. d’une dizaine d’éléments contrôlant l’épissage alternatif des exons mutuellement exclusifs IIIb et IIIc de FGFR2 ont été identifiés (figure 3A). Bien que les. Causes d’altération de l’épissage alternatif dans les cancers. A) Mutations affectant l’épissage alternatif et quelques exemples de gènes ayant subi ce type de.
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Splicing factors and spliceosome components recognize splicing signals and regulatory sequences of the pre-mRNAs. Previous article Next article. In which subject field?
Language Portal of Canada Access a collection of Canadian resources on all aspects of English and French, including quizzes. Initial download of the metrics may take a while. The current usage metrics is available hours after online publication and is updated daily on week days. Here we discover a class of human genes, in which the last exon appeared recently during evolution, and the major gene product uses an alternative 3′-terminal exon corresponding to the ancestral last exon of the gene.
Document Actions Export Bibliography. Alternatof splicing sequences make splicing susceptible to polymorphisms and mutations.
FAQ Frequently asked questions Display options. Skip to navigation Personal tools Epussage in. Issue Med Sci Paris. Although many alterations are caused by mutations in splicing sequence i. Metrics Show article metrics. Data correspond to usage on the plateform after Services Articles citing this article CrossRef 2.
Current usage metrics About article metrics Return to article. This mechanism is highly regulated to precisely modulate detection of specific splice sites.
Presentation — Laboratoire de Biologie et Modélisation de la Cellule
Change the order of display of the official languages of Canada English first French first Option to display the non-official languages Spanish or Portuguese Neither Spanish Portuguese Display definitions, contexts, etc. Info A recently evolved class of alternative 3′-terminal exons involved in alternativ cycle regulation by topoisomerase inhibitors. It is a method of producing structurally and functionally distinct proteins from the same gene and a method of developmental regulation.
A collection of writing tools that cover the many facets of English and French grammar, style and usage. Link to PubMed entry. Search Site only in current section. HuR binding to the alternative 3′-terminal exon in the pre-messenger RNA promotes its splicing, and is reduced by topoisomerase inhibitors. The generation of two or more different mature mRNA’s from the same primary transcript through variation in the sites of splicing.
Alternative splicing and tumor progression
Access a collection of Canadian resources on all aspects of English and French, including quizzes. Abstract Alternative 3′-terminal exons, which use intronic polyadenylation sites, are generally less conserved and expressed at lower levels than the last exon of genes. This regulation is under control of the spliceosome and several splicing factors are also required to modulate the alternative usage of splice sites.
Med Sci Paris ; Writing tools A collection eipssage writing tools that cover the many facets of English and French grammar, style and usage. Glossaries and vocabularies Access Translation Bureau glossaries and vocabularies.
Epissage Alternatif by Peter Oriane on Prezi
The language you choose must correspond to the language of the term you have entered. These findings provide new insights into the evolution, function andmolecular regulation of alternative 3′-terminal exons.
Following growing of knowledge regarding splicing regulation, several approaches have been developed to compensate for the effect of deleterious mutations and to restore sufficient amounts of functional protein.
Alternative 3′-terminal exons, which use intronic polyadenylation sites, are generally less conserved and expressed at alternatkf levels than the last exon of genes. This novel class of alternative 3′-terminal exons are downregulated on a large scale by doxorubicin, a cytostatic drug targeting topoisomerase II, and play a role in cell cycle regulation, including centromere-kinetochore assembly.
Examples of associations between human rare diseases and defects in pre-messenger RNA splicing are accumulating. Most of protein-coding human genes are subjected to alternative pre-mRNA splicing.