Compare Anti-Glucose Transporter GLUT3 antibody ab from Abcam on Be the first to write a review! Rabbit polyclonal to Glucose Transporter GLUT3. C5 and T4 cells showed the highest rate of GLUT-3 expression. These cells were ORL J Otorhinolaryngol Relat Spec. ;– glucose transporter 3 (GLUT3)2 is the major GLUT subtype in .. platelets without additional Ca2 at 20 °C in a F fluorescence spec-.
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GLUT – The OpenGL Utility Toolkit
In other series, Glut3 expression is relatively high in aggressive tumors including breast, choriocarcinoma and lung tumors [ 410 ]. On the origin of cancer cells. Abstract Introduction Increased glucose uptake and glycolysis are main metabolic characteristics of malignant cells.
Estradiol and BP showed similar phenotypical, but different genomic alterations [ 40 ]. Differential expression of flut3 glucose transporters in normal and tumour kidney tissues. Statistical analysis Two-tailed unpaired t test was used for gene expression analysis.
The all comparisons were significant. Maximum number of solid mass formation was observed in E2 group. Pereira3 J.
Expression and localization of Glut1 and Glut 12 glucose transporters in the pregnant and lactating rat mammary gland. Growth factor signalling networks in the breast cancer and resistance to endocrine agents: Although, estrogenic regulation of glucose transporters on mammary epithelium is unclear. J Mammary Gland Biol Neopl.
Differential regulation of glucose sspec expression by estrogen and progesterone in Ishikawa endometrial cancer cells.
Introduction Mammalian cells use a wide variety of plasma-membrane transport systems in order to translocate several substrates into spex cell.
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The glycolytic phenotype in carcinogenesis and tumor invasion: Discussion In the present study, we attempted to identify the gene expression profiles of particular GLUTs in an isogenic group of cell lines in order to better understand the stages of specific alterations sprc estrogen-induced carcinogenesis.
On the other hand, estrogenic action on breast cancer progression spwc malignant transformation have been found to be related to gut3 regulation of glucose transporter proteins [ 4 ].
Breast differentiation and its implication in cancer prevention. Kocdor2 J. Biochem Biophy Res Commun. Deregulated simultaneous expression of multiple glucose transporter isoforms in malignant cells and tissues. Concordant with this suggestion, Rivenzon-Segal and co-workers [ 55 ] have found that differentiation of the breast cancer cell line T47D with retinoic acid led to a reduction in Glut-1 and to an increase in cytoplasmic Glut-3 as well as decreased glycolysis.
For example, following early-full term pregnancy and lactation periods, terminally differentiated gult3 epithelium becomes resistant to E2-induced carcinogenesis [ 3054 ]. Hypoxia inducible factor-1 alpha and the glycolytic phenotype in tumors. For example, loss of 9p, LOH D13S, Delp53 exon4, persisted in all transformed cells; complete loss of chromosome 4 was observed in C5 and T4 cells.
Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. High correlations between primary tumours and loco-regional metastatic lymph nodes in non-small-cell lung cancer with respect to glucose transporter type 1-mediated 2-deoxy-2Ffluoro-d-glucose uptake. CA Cancer J Clin. Cancer cells, similar to non-tumoral mammalian cells, utilize glucose as main energy substrate using only these facilitative transport systems GLUTs depending on their increased metabolic activity and rapid proliferation [ 34 ].
The publisher’s final edited version of this article is available at Clin Transl Oncol.
These alterations are appearing related to metabolic rates vlut3 transformed cells or tumors and their aggressive behavior. Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer. Comparative genomic hybridization CGH revealed cumulative genomic changes in all transformed cell lines.
Footnotes Conflict of interest The authors have nothing to disclose. Recently, high correlations between the primary tumors and metastatic lymph nodes with respect to Glut1 expression have been observed in several invasive tumors [ 4849 ].
In addition, tumoral tissue continues its own estrogen production by increasing intra-tumoral aromatase activity [ 32 ]. Airley RE, Mobasheri A. The quality and quantity of each sample were verified by spectrophotometry using NanoDrop 3.
This hormone is also particularly effective in further stages, for example acceleration of the cellular growth and progression of the premalignant xenografts [ 31 ].