Histoid leprosy is a skin condition, a rare form of multibacillary leprosy See also[edit]. Leprosy · Skin lesion. References[edit]. ^ James, William D.; Berger. Histoid leprosy, an uncommon variant of lepromatous leprosy, develops usually as relapse in lepromatous patients who are on dapsone. Summary Histoid leprosy is a rare multibacillary form that presents with disseminated papule-nodular cutaneous lesions. To study the inflammatory infiltrate.

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It is characterized by cutaneous and subcutaneous nodules. However, specific histopathology of histoid leprosy differentiates it from LL type which shows macrophage granuloma with variable amount of foamy changes with innumerable bacilli and globi and ENL reaction which shows features of acute inflammation predominantly having neutrophils accompanied by edema along with granular AFB.

Our patient was elderly, aged Here we report two cases of leeprosy leprosy of histoid type, one with histiid and another with atypical presentations.

Am J Trop Med Hyg. An increase in both cell-mediated and humoral immunity against Mycobacterium lepraeas in lepromatous leprosy, has been hypothesized. Histoid leprosy might represent an enhanced response of the multibacillary disease in localizing the disease process. The histopathological features are distinct and contribute to the nomenclature of the condition.

Actinobacteria primarily A00—A79—, — Leprosy relapse presenting in a histoid form after multidrug therapy. None, Conflict of Interest: Histoid leprosy Histoid leprosy is a skin condition, a rare form of multibacillary leprosy.

De-novo Histoid Leprosy

It is a variant of lepromatous leprosy. Histoid leprosy is a distinct and rare variant of lepromatous leprosy, and it was described by Wade 1 in It is so-called because the microscopic appearance of the nodule shows spindle-shaped cells resembling those in a dermatofibroma.


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Muller J Med Sci Res ;4: A histopathological examination of the skin lesion was ordered which revealed sheets of histiocytes and lepra bacilli on hematoxylin and eosin and acid fast staining. HL has characteristic clinical, histopathological, and bacterial morphological features. There is a male preponderance, and the average age at diagnosis is between 21 and 40 years. Corynebacterium diphtheriae Diphtheria Corynebacterium minutissimum Erythrasma Corynebacterium jeikeium Group JK corynebacterium sepsis.

Abstract Histoid leprosy is rare type of lepromatous leprosy characterized by unique clinical, histopathological, and microbiological features. Histoid leprosy in North India. Related articles Multibacillary multidrug therapy Elimination. Each of them can be differentiated from the histoid leprosy on the basis of its characteristic histopathology, the leproxy of lepra bacilli on slit skin smear and nerve thickening. How to cite this URL: Histoid leprosy is not uncommon in South India. Histoid leprosy is an uncommon leprrosy with specific clinical, histopathological and bacteriological features.

Support Center Support Center. Histopathology revealed focal epidermal atrophy with an underlying cellular band. Histoid, a clinical variant of multibacillary leprosy: Bacterium-related cutaneous conditions Infection-related cutaneous condition stubs.

Lepromatous leprosy of histoid type Annigeri S R, Metgud S C, Patil J R – Indian J Med Microbiol

Their number may vary from 3—50 [ 1 ]. Lepromatous leprosy of histoid type: Scalp, ears, oral cavity, palms, soles, and genitalia were spared. The lesions are usually located on the posterior and lateral aspects of arms, buttocks, thighs, dorsum of hands and on the lower part of the back and over the bony prominences, especially over the elbows and knees [ 2 ].

We describe here a case of histoid leprosy, clinically mimicking neurofibromatosis. Abstract Histoid leprosy is an uncommon entity with specific clinical, histopathological and bacteriological features. Bilateral ulnar nerves and right common peroneal nerve were thickened, non-tender. FNAC is a simple cost-effective method of investigation that is more useful in tuberculoid, lepromatous, and histoid leprosy patients. The slit skin smear and histopathological examination confirmed the diagnosis of histoid Hansen; a case arising de novo in an elderly.


This article has been cited by other articles in PMC. Histoid leprosy is rare type of lepromatous leprosy characterized by unique clinical, histopathological, and microbiological features.

The most prominent feature is the presence of numerous spindle-shaped histiocytes arranged in interlacing bands, whorls, and tight curlicues. A year-old farmer presented with shiny, nonitching nodules, papules, and plaques over various parts of body especially prominent over trunk, lower back, buttocks, arms, and legs but involving face, chest wall, elbow, and knee, counting approximately 42 in number Figures 1 a — 1 c.

Fine needle aspiratin cytology in leprosy. Responsible factors may include: Fine needle aspiration cytology FNAC of the back and arm nodule showed round-to-elongated, benign, spindle cells, with cytoplasmic vacuolation. The dermis showed sheets of round-to-spindle-shaped histiocytes compressing the skin appendages. Indian J Med Microbiol. Histopathology of the lower back nodule showed atrophic epidermis with a subepidermal grenz zone.

Case Reports in Pathology

A report of three cases. Sehgal VN, Srivastava G.

In India, its incidence among leprosy patients is estimated to be 2. Clinically it is characterized by cutaneous and or subcutaneous nodules and papules, which are painless, firm, discrete, smooth, globular, skin-colored to yellowish-brown, with apparently normal skin surrounding it.

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