As Disintegrating agent: Kyron T has a very high swelling tendency of hydration either in contact with water or G.I. fluids causing fast disintegration without. Article | The purpose of present study was to compare Kyron T with other superdisintegrants and optimize the fast dissolving tablet of. industry to mask the taste of bitter medicine to achieve stability and drugs. It is white to off white fine powder, swellable in water. KYRON T is derived from.
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The co-processed superdisintegrants were evaluated for their flow and compression properties in comparison with physical mixture of superdisintegrants.
Get in Touch with us Corel Pharma Chem. The result of flow property of formulations indicates that the blends were free flowing. The punches and die were lubricated with a kygon amount of magnesium stearate using a cotton swab preceding compression.
Kyron T – View Specifications & Details by Corel Pharma Chem, Ahmedabad | ID:
The flow prpoperties were shown in Table 3. The tablets containing co-processed superdisintegrants in a ratio of 1: Wetting time and water absorption ratio which is an important criteria for understanding the capacity y-314 superdisintegrants to swell in the presence of little amount of water was found to be in the range of College of Pharmacy, Chandwad Nasik India.
SammourMohammed A. Tablets formulated using a combination of coprocessed crospovidone A and Kyron T B 1: Analysis of drug release data indicated that formulation F-X followed first order kinetics.
Required quantity is from 2. Dietary Potassium Search for additional papers on this topic.
FTIR spectra of the crospovidone, Kyron T, physical blend and co-processed mixture of superdisintegrants in ratio of 1: Direct compression, co-processed superdisintegrants, solvent-evaporation, crospovidone, Kyron T, metoclopramide hydrochloride, wetting time.
Kyron T has a very high swelling tendency of hydration either in contact with water or G. WaghSapna S. Kyron T breaks the tablets into very smaller particles, thus it increases the effective surface area for the absorption of the active substances and thus it increases the dissolution and bioavailability of the active substances.
Stability study was conducted as per ICH guidelines. This study revealed that the co-processed mixture of superdisintegrants have excellent flow properties, high compressibility, render low disintegration time to tablets and have better binding properties as compared to physical blends of superdisintegrants.
The bulk density was determined as the ratio of weight to the volume of sample. In order to attain maximum customer satisfaction, we have with us a well equipped testing unit which is fitted with instruments like UV spectrometer, HPLC, GC, Brookfield viscometer and Stability chamber. The authors are also grateful to Gujarat Microwax Pvt. Hardness of the tablet, which is the force applied across the diameter of the tablet to break a tablet into halves, was measured using a Pfizer tablet hardness tester.
User Username Password Remember me. It was noted as wetting time. Granulation procedure Tablet Dosage Form. Aceclofenac in the management of inflammatory pain. Melt-in-mouth tablets each containing 10 mg of metoclopramide hydrochloride were prepared by direct compression method employing crospovidone, Kyron T, physical blend and co-processed mixture of both the superdisintegrants in different ratios 1: The dried granules were sifted on sieve and stored in air tight container till further use [ 10 ].
Unique porous particle morphology facilitates wicking of liquid into the pores of the tablet and makes it suitable for direct compression [ 8 ]. A blend of crospovidone and Kyron T in the ratio of 1: Comparison between wetting time and in vitro dispersion time of all the prepared formulations is shown in fig.
Results of wetting time and water absorption ratio determined are tabulated in Table 4 and 5. PatilKaveri R. Required quantity is from 0. Call Send a quick message. The simple physical blends and co-processed mixture of superdisintegrants were characterized for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio and compatibility studies by FTIR spectroscopy.
Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion Omaima A. Disintegrant Excipient Tablet computer Compliance behavior. It was observed that the tablets with shortest wetting time showed minimum disintegration time.
It has no physiological action at recommended dosage and it is non toxic. Zero-order rate equation describes the one whose rate is independent of the concentration of drug undergoing reaction, while the first-order rate equation describes the one whose rate is directly proportional to the concentration of drug undergoing reaction.
The prepared mixture was evaluated for flow properties and polymer-polymer compatibility studies such as FTIR study.